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■ページ数 9ページ



Distribution Analysis of Axonal Conduction Delay in In vitro Reconstructed Sensory Fiber

■著者名 酒井 洸児(東京大学大学院 工学系研究科),榛葉 健太(東京大学大学院 工学系研究科),小谷 潔(東京大学 先端科学技術研究センター),神保 泰彦(東京大学大学院 工学系研究科)
■著者名(英語) Koji Sakai (School of Engineering, The University of Tokyo), Kenta Shimba (School of Engineering, The University of Tokyo), Kiyoshi Kotani (Research Center for Advanced Science and Technology, The University of Tokyo), Yasuhiko Jimbo (School of Engineering, The University of Tokyo)
■価格 会員 ¥550 一般 ¥770
■書籍種類 論文誌(論文単位)
■グループ名 【C】電子・情報・システム部門
■本誌 電気学会論文誌C(電子・情報・システム部門誌) Vol.141 No.12 (2021) 特集T:電気・電子・情報関係学会東海支部連合大会 特集U:研究会優秀論文
■本誌掲載ページ 1331-1339ページ
■原稿種別 論文/日本語
■電子版へのリンク https://www.jstage.jst.go.jp/article/ieejeiss/141/12/141_1331/_article/-char/ja/
■キーワード 軸索,活動電位伝播,感覚神経細胞,微小電極アレイ,培養チャンバ  axon,action potential conduction,sensory neuron,microelectrode array,culture chamber
■要約(英語) Understanding information processing in peripheral somatosensory pathway is essential for revealing mechanisms account for sensory impairments. To investigate cellular functions under in vivo-like conditions, many cell-culture systems for mimicking the structure of somatosensory fibers have been developed. However, there remains a difficulty in detecting electrophysiological properties of individual axons from the axon bundle. To address this, we proposes two analytical methods of evaluating conduction properties of axons using a culture device which allows for multi-site recording of extracellular potentials from an axon bundle. First, we tried to estimate velocity distribution of axons by electrical stimulations. Using the relationships between excitability and conduction velocity, we classified axons into two groups (0.57 m/s and 0.43 m/s) based on analysis of response waveforms evoked by electrical stimulations. Second, we investigated propagation properties of capsaicin-induced action potentials in individual axons. Localized application of capsaicin into the distal part of axons elicited antidromic propagation (68% of total propagations) and induced high-frequency activity (> 10 Hz) which leads to slowing of conduction velocity (12% of initial velocity). These phenomena are related to in vivo somatosensory processing, indicating that the methods will be a useful tool for studying somatosensory processing at the cellular level.
■版 型 A4
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